Are granulosa cell tumors genetic?


Can granulosa cell tumors spread?

Spread is largely within the pelvis and the lower abdomen. Distant metastases are rare with few reported cases of lung, liver, brain, bone, diaphragm, abdominal wall, adrenal gland and supraclavicular lymph node metastasis from ovarian tumors.

Can a granulosa cell tumor be benign?

GCTs are thought to be tumors of low malignant potential. Most of these tumors follow a benign course, with only a small percentage showing aggressive behavior, perhaps due to early stage at diagnosis. Metastatic disease can involve any organ system, although tumor growth usually is confined to the abdomen and pelvis.

How often do granulosa cell tumors recur?

The median follow-up period was 88 months (range 6–498). Of these, 33 patients had at least one episode of disease recurrence, with a median time to recurrence of 53 months (range 9–332). Also, 47% of recurrences occurred after 5 years from initial diagnosis.

Is granulosa ovarian cancer hereditary?

Ovarian sex cord-stromal tumors (SCST) represent approximately 8% of malignant ovarian tumors. The most common are granulosa cell tumors (GCT) which account for approximately 90% of malignant SCST. Recent studies have unraveled the key genomic and genetic events contributing to their pathogenesis.

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Is granulosa cell tumor curable?

For patients with stage II-IV granulosa cell tumors, postoperative treatment is recommended,[5,6] but the survival benefit is still not known due to rarity of these tumors and lack of randomized trials.

What are the symptoms of granulosa cell Tumour?

These may include increased linear growth, breast enlargement, clitoral enlargement, pubic hair development, increased vaginal secretions, and vaginal bleeding. In a few instances, patients present with virilizing symptoms as a result of testosterone production by the tumor cells.

Is granulosa cell tumor malignant?

Ovarian granulosa cell tumor (GCT) is a malignant tumor with slow progression. The recurrence of granulosa cell tumor often happens after 5 years, leading to a ‘forgotten tumor’ by the patient.

Do ovarian tumors grow fast?

Ovarian cancer grows quickly and can progress from early stages to advanced within a year. With the most common form, malignant epithelial carcinoma, the cancer cells can grow out of control quickly and spread in weeks or months.

Can giant cell tumor come back?

Tumors that can’t be removed with surgery can often be controlled and sometimes destroyed with radiation therapy. Giant cell tumors can come back. Follow-up with your healthcare provider may be needed for several years.

What is the tumor marker for granulosa cell tumor?

Lappöhn et al showed that inhibin can be used as a marker of granulosa cell tumors (GCT). Inhibin ia s glycoprotein specifically produced by ovarian granulosa cells.

What does high inhibin B mean?

The amount of inhibin B measured in serum during the early follicular phase of the menstrual cycle (day 3) directly reflects the number of follicles in the ovary. Therefore, the higher the inhibin B, the more ovarian follicles present.

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