Does Chemo help enlarged spleen?
The chemotherapy drug, hydroxyurea (Hydrea®) may be given to reduce high platelet and white blood cell counts. It may also help treat other MF symptoms including an enlarged spleen, night sweats and weight loss.
Can an enlarged spleen go back to normal size?
What Is the Prognosis for Enlarged Spleen? Depending upon the cause, the enlarged spleen may return to normal size and function when the underlying disease is treated or resolved. Commonly, in infectious mononucleosis, the spleen returns to normal as the infection gets better.
How does chemo affect the spleen?
Chemo has it’s potential to destroy B and T cells, and other cells therefore we can expect that it can destroy lymphocytes/plasmocytes from spleen. Spleen as an lymphoid organ, consists mostly of B cells, and T cells in so called T dependent zones, such as PALS.
How successful is hydroxyurea for treating enlarged spleen?
Cytoreductive treatment, usually hydroxyurea, is the first-line therapy, being effective in around 40% of the patients, although the effect is often short lived. The immunomodulatory drugs, such as thalidomide or lenalidomide, rarely show a substantial activity in reducing the splenomegaly.
How can I shrink my enlarged spleen?
Some drugs can shrink an enlarged spleen. Your doctor might try chemotherapy, immunomodulators, and a drug called ruxolitinib (Jakafi). Radiation might help, too. However, you may need surgery to remove an enlarged spleen.
What to avoid if you have an enlarged spleen?
Avoid contact sports — such as soccer, football and hockey — and limit other activities as recommended by your doctor. Modifying your activities can reduce the risk of a ruptured spleen. It’s also important to wear a seat belt.
How can I reduce an enlarged spleen naturally?
There are no natural treatments for an enlarged spleen.
What is myelofibrosis?
Myelofibrosis is an uncommon type of bone marrow cancer that disrupts your body’s normal production of blood cells. Myelofibrosis causes extensive scarring in your bone marrow, leading to severe anemia that can cause weakness and fatigue.