Best answer: What are the major subtypes of breast cancer?

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What is the most common subtype of breast cancer?

The luminal-A is the most common subtype and represents 50%-60% of all breast cancers. These tumors frequently have low histological grade, low degree of nuclear pleomorphism, low mitotic activity and include special histological types (i.e., tubular, invasive cribriform, mucinous and lobular) with good prognosis.

What are the four main genetic subtypes of invasive breast cancer?

With the aid of hierarchical clustering analyses, 4 distinct molecular subgroups of invasive breast cancer were described: ER+/ luminal-like, basal-like, HER2 enriched and normal breastlike.

What is the most aggressive subtype of breast cancer?

Triple negative breast cancer (TNBC) is a more aggressive subtype of breast cancer and is characteristic of the absence of the expressions of estrogen receptor, progesterone receptor, and human epithelial growth factor receptor 2 in breast tumor tissues.

How common is HR+ breast cancer?

The breast cancer subtype HR+/HER2- is the most common subtype with an age-adjusted rate of 88.1 new cases per 100,000 women, based on 2014–2018 cases.

At a Glance.

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Subtype Percent of Cases
HR+/HER2- 68.1887970532625%
HR-/HER2- 10.1148189890482%
HR+/HER2+ 10.3906324027328%
HR-/HER2+ 4.22416512608076%

How do you classify breast cancer?

The current molecular classification divides breast cancer into five groups as luminal A, luminal B, HER-2, basal and normal breast like. Further grouping of these subgroups seem possible and necessary.

What is the easiest breast cancer to treat?

Invasive breast cancers are staged I through IV, with stage I being the earliest stage and easiest to treat, while stages II and III represent advancing cancer, with stage IV representing breast cancer cells that have spread (metastasized) to distant organs like the bones, lungs, or brain.

What is the fastest growing breast cancer?

Inflammatory breast cancer, which may be detected in the ducts or lobules, tends to spread faster than other types of breast cancer. This quick-growing, aggressive disease makes up about 1 to 5 percent of breast cancers in the United States, according to the NCI.

Which breast cancer subtype has the best prognosis?

Results: Luminal A was the most commonly diagnosed subtype (59.0%) and had the greatest survival, whereas triple-negative had the poorest survival.

Which of the following is the most common histologic type of breast cancer?

The major invasive tumor types include infiltrating ductal, invasive lobular, ductal/lobular, mucinous (colloid), tubular, medullary and papillary carcinomas (Fig. 1). Of these, infiltrating ductal carcinoma (IDC) is, by far, the most common subtype accounting for 70–80% of all invasive lesions.

What does ER positive mean in breast cancer?

Hormone status of breast cancers includes: Estrogen receptor (ER) positive. The cells of this type of breast cancer have receptors that allow them to use the hormone estrogen to grow. Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells.

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