Best answer: What are the pathologic prognostic factors for endometrial carcinoma?


What factors affect the prognosis of endometrial cancer?

The factors influencing survival were age, myometrial invasion and lymph node metastasis. Conclusion: Lack of myometrial invasion, absence of lymph node metastasis and age younger than 60 years seem to be the most significant predicting factors of survival.

What is the most important prognostic factor in endometrial hyperplasia?

Surgical stage is the most significant prognostic variable for endometrial cancer. Data from GOG 33 looked at surgical and pathologic factors that were associated with extrauterine disease, lymph node involvement and recurrence in clinical early-stage disease.

What is the major determinant of prognosis in the endometrial Ca?

Multiple prognostic factors exist for endometrial cancer. These prognostic factors generally are related to surgical pathologic findings. As in all cancers, the stage of the disease is the most important prognostic factor.

How long can you live with untreated endometrial cancer?

Five other cases of untreated endometrial carcinoma were found in the literature. The patients had varying length of survival (range: 5 months to 12 years), but all patients experienced generally good health several years after diagnosis.

How long does it take for endometrial cancer to develop?

This cancer usually develops after menopause, most often in women aged 50 to 60. Over 90% of cases occur in women over 50. About 75 to 80% of endometrial cancers are adenocarcinomas, which develop from gland cells.

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What is Melf pattern?

Microcystic, elongated, and fragmented (MELF) glands are a myometrial invasion pattern associated with angiolymphatic invasion and lymph node metastasis. They may acquire increased p16 and cyclin D1 expression, loss of e-cadherin, and may shed small fragments of cytoplasm comprising oncosomes.

What does endometrial hyperplasia Mean?

Endometrial Hyperplasia: A condition in which the lining of the uterus grows too thick. Endometrial Intraepithelial Neoplasia (EIN): A precancerous condition in which areas of the lining of the uterus grow too thick. Endometrium: The lining of the uterus. Estrogen: A female hormone produced in the ovaries.

What is the death rate of endometrial cancer?

The 5-year survival rate for people with uterine cancer is 81%. The 5-year survival rates for white and Black women with the disease are 84% and 63%, respectively. Black women are more likely to be diagnosed with more aggressive endometrial cancers with lower survival rates.