Is High B12 linked to cancer?

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Should I be worried if my B12 is high?

There is no upper limit for vitamin B-12 intake because consuming high levels does not cause problems. However, having naturally high levels of vitamin B-12 in the body may be a cause for concern, as it suggests a severe underlying condition.

Does high B12 mean cancer?

Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevated B12.

What cancers cause high B12 levels?

Other studies focusing on specific cancers have shown a strong association between elevated B12 levels and liver cancers (OR 3.3 [95%CI: 1.1–10.4] for hepatocellular carcinomas and OR 4.7 [95%CI: 1.2–17.9] for other liver cancers) [16], a moderate association with prostate cancer (OR 1.1 [95%CI: 1.0–1.2]) [17], and no …

What does it mean if your B12 is too high?

The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12. We don’t worry about overdosing on B12 supplements because excess can be excreted in your urine. It could also be possibly from your diet if high in animal products such as meat, eggs, and shellfish.

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What is the treatment for high vitamin B12?

You can change your diet to include vitamin B12-fortified grains, a supplement or B12 injections, or a high-dose oral vitamin B12 if you are deficient. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12.

What are the symptoms of high B12 levels?

High doses of vitamin B-12, such as those used to treat a deficiency, might cause:

  • Headache.
  • Nausea and vomiting.
  • Diarrhea.
  • Fatigue or weakness.
  • Tingling sensation in hands and feet.

What causes high vitamin B12 levels without supplements?

High or supraphysiological serum B12 levels without supplementation have been associated with many pathological conditions including renal failure, haematological disorders, cancer, and hepatic or autoimmune diseases. All conditions may show elevated concentrations of B12 transport proteins.

Is B12 level of 1500 too high?

There is no consensus on the definition of high or elevated B12. Previous studies have chosen a variety of levels to represent high or very high B12 (pmol/l) levels. Some examples include: 664.219; 5131; 700 (high) and 1500 (very high)11; and 601 (high) and 1000 (very high)10.

Is B12 level of 1100 too high?

The normal range for vitamin B12 (total) is between 200 – 1100 ng/L (nanograms per liter), 200 – 1100 pg/mL (picograms per milliliter), or 148 – 811 pmol/L (picomoles per liter). The normal range for active vitamin B12 (holoTC) is around 20 – 134 pmol/L (picomoles per liter).

Is high vitamin B12 common?

An increased vitamin B12 level is uncommon. Usually, excess vitamin B12 is removed in the urine. Conditions that can increase B12 level include: Liver disease (such as cirrhosis or hepatitis)

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Is B12 level of 2000 too high?

Though doses of up to 2,000 mcg of vitamin B12 are considered safe, it’s best to speak to a doctor to find out whether taking a supplement is necessary. Most people can fill their B12 needs through a healthy diet. Some, such as older adults or those with certain dietary restrictions, should supplement.

Can lupus cause high B12 levels?

Cases of Gaucher disease, systemic lupus, rheumatoid arthritis and Still’s disease with high serum cobalamin have also been reported. High serum cobalamin in dysimmune and inflammatory diseases may be linked to an increase in TCB II during the acute phase of inflammation.