Question: Why is chemo given intrathecal?

Why are intrathecal cytotoxics given during treatment for all?

Why do I need intrathecal chemotherapy? With some types of cancer, cancer cells can pass into the CSF. Chemotherapy given by mouth or intravenous injection cannot cross over into CSF. The best way to treat cancer in the CSF or prevent cancer from spreading to the CSF is to give chemotherapy directly into the fluid.

Is intrathecal injection painful?

Intrathecal chemotherapy

Because of the short half-life of cytotoxic agents (methotrexate and cytarabine), frequent intrathecal injections (lumbar punctures) are necessary, which are painful and inconvenient for the patient.

Where do intrathecal drugs go?

Intrathecal drug administration is the introduction of a therapeutic substance into the cerebrospinal fluid by injection into the subarachnoid space of the spinal cord to bypass the blood-brain barrier. The main indications are for anesthesia and pain management.

Is Intrathecal the same as epidural?

Intrathecal administration is delivered directly into the CSF and into the superifical spinal cord; epidural administration diffuses through the dura into the CSF, and thus has a slower onset of action.

What drugs can be given Intrathecally?

Currently there are only three medications approved by the US Food and Drug Administration (FDA) for use via the intrathecal route, ie, morphine, ziconotide, and baclofen.

Table 3.

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Drug Recommended starting dosage
Ziconotide 0.5–2.4 mcg/day
Fentanyl 25–75 mcg/day
Bupivacaine 1–4 mg/day
Clonidine 40–100 mcg/day

When do you give intrathecal chemotherapy?

If you have a diagnosis of cancer that affects your central nervous system (brain and spinal cord), your doctor may recommend intrathecal chemotherapy treatment. Intrathecal chemotherapy is a type of cancer treatment that targets your cerebrospinal fluid (CSF).

Who can check intrathecal chemotherapy?

The intrathecal chemotherapy injection must be checked prior to administration by the Consultant Haematologist, Staff Grade or Associate Specialist and one other person trained in the administration of chemotherapy and therefore authorised to do so (Appendix 1).

How do you administer intrathecal chemotherapy?

How Is IT Chemo Given? One way to get this treatment is with a lumbar puncture, or spinal tap. This is the same method used to get a sample of your fluid to test for cancer cells. Your doctor will use a needle and syringe to deliver the medicine into your CSF between two vertebrae in your spine.

What is the purpose of intrathecal injection?

An intrathecal injection can help control pain after surgery. An anesthesiologist injects a single dose of narcotic (opioid) medicine around your spinal cord. One injection will last up to 24 hours after it is given. An intrathecal injection can reduce the amount of other medicines needed to control your pain.

How long does an intrathecal pump last?

The pump is a disk about 1 inch thick and 3 inches wide. It contains medicine and has a battery that lasts for 5 to 7 years.