What does Oncocytic mean?
Oncocytes are cells that have abundant eosinophilic cytoplasm due to the accumulation of mitochondria; they are also known as oxyphils.
What is an Oncocytic tumor?
Oncocytic neoplasms are tumors composed of cells characterized by an aberrant amount of mitochondria that is responsible for their “swollen” (i.e. oncocytic) appearance .
Is an Oncocytic neoplasm malignant?
Background: Oncocytic carcinoma (OC) arising in the submandibular gland is an unusual malignant neoplasm, with <20 cases previously reported. The cancer is characterized by numerous morphologically abnormal mitochondria present in the cytoplasm and marked cellular pleomorphism.
What is Oncocytic change?
Oncocytic change is defined as cellular enlargement characterised by an abundant eosinophilic granular cytoplasm as a result of the accumulation of altered mitochondria. This is a phenomenon of metaplasia that occurs in inflammatory disorders, such as thyroiditis, or other situations that result in cellular stress.
What is a hurthle cell?
Hurthle cells are a particular type of thyroid cell that can be found in both benign and cancerous thyroid nodules. Therefore, when seen in a thyroid biopsy sample, Hurthle cells often lead to an indeterminate diagnosis.
How common are oncocytomas?
Renal oncocytomas are common benign kidney neoplasms that account for 3 to 7 percent of renal neoplasms. They usually occur in adults, most frequently in the seventh decade of life. Renal oncocytomas may be discovered incidentally or may be diagnosed with biopsy or excision.
Are adenomas always benign?
Adenomas are generally benign or non cancerous but carry the potential to become adenocarcinomas which are malignant or cancerous. As benign growths they can grow in size to press upon the surrounding vital structures and leading to severe consequences.
What is neoplasm disease?
(NEE-oh-PLA-zum) An abnormal mass of tissue that forms when cells grow and divide more than they should or do not die when they should. Neoplasms may be benign (not cancer) or malignant (cancer).
What is Oncocytic neoplasm of kidney?
Oncocytoma is a term generally used to describe a neoplasm of the renal parenchyma consisting of well-differentiated cells with prominently eosinophilic granular cytoplasm. We report our experience with such tumors and with 4 cases of granular cell carcinoma (grade 2).
What is Bethesda Category V?
Biopsy results can fall within one of six categories as defined by the Bethesda system for reporting FNA cytopathology results: I (non-diagnostic), II (benign), III (atypia of undetermined significance/follicular lesion of undetermined significance), IV (follicular neoplasm), V (suspicious for malignancy), and VI ( …
What causes Oncocytoma?
When renal oncocytomas are part of a genetic syndrome, they are caused by changes ( mutations ) in a specific gene . Tuberous sclerosis complex is caused by mutations in the TSC1 gene or TSC2 gene, while Birt-Hogg-Dube syndrome is caused by mutations in the FLCN gene.