What is a tumor suppressor protein?
A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA) in tumor suppressor genes may lead to cancer. Also called antioncogene.
How do tumor suppressor proteins prevent cancer?
Tumor suppressor genes make proteins that regulate the growth of cells, and they play an important role in preventing the development of cancer cells. Tumor suppressor genes are also known as antioncogenes or loss-of-function genes.
What is an important tumor suppressor protein?
p16 is a tumor suppressor protein that plays an important role in regulating the cell circle. As a CDK inhibitor, p16 can slow down the progression of the cell cycle by inactivating the CDK that phosphorylates the retinoblastoma protein, which is also a tumor suppressor protein that regulates the cell circle.
What gene is responsible for tumor suppression?
The p53 tumor-suppressor gene deficiency is observed in most cancers. The p53 gene has been shown to be involved in the control of the cell cycle, transcriptional regulation, DNA replication, and induction of apoptosis. The p53 gene can suppress cell transformation and malignant cell growth.
Which is an example of a tumor suppressor protein?
Well-described examples of tumor suppressor proteins include RB, p53, APC and CDKN2A/p14 ARF.
How does p53 work as a tumor suppressor?
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.
What are the three ways to treat cancer?
Types of Cancer Treatment
- Radiation Therapy.
- Targeted Therapy.
- Stem Cell or Bone Marrow Transplant.
- Hormone Therapy.
What happens if a tumor suppressor gene mutates?
When a proto-oncogene mutates (changes) or there are too many copies of it, it becomes a “bad” gene that can become permanently turned on or activated when it is not supposed to be. When this happens, the cell grows out of control, which can lead to cancer.
How can a tumor suppressor gene lose its function?
Mutations that inactivate tumor suppressor genes, called loss-of-function mutations, are often point mutations or small deletions that disrupt the function of the protein that is encoded by the gene; chromosomal deletions or breaks that delete the tumor suppressor gene; or instances of somatic recombination during …
Does chemotherapy restore tumor suppressor gene function?
Small-molecule inhibitors used in cancer therapy restore the functions of various tumor suppressors in malignant cells.
How p53 is different from other tumor suppressor gene?
In most cases, the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is regarded as a hallmark of cancer cells. Mutant p53 proteins not only lose their tumor suppressive activities but often gain additional oncogenic functions that endow cells with growth and survival advantages.