What is metastatic endometrial carcinoma?

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How is metastatic endometrial cancer treated?

Management options include hormonal therapy and cytotoxic chemotherapy, as well as targeted therapies that inhibit angiogenesis and the cellular signaling pathways involved in cell growth and proliferation. A comprehensive review of these treatments for metastatic endometrial cancer was conducted and is discussed.

How long can you live with metastatic uterine cancer?

Five-year survival rate was 5.7% (95% confidence interval: 0.0-13.3), and median survival was 7.6 months. Survival of patients with a single metastasis at the time of diagnosis was longer than for patients with multiple metastases (16 versus two months, respectively; p < 0.00 1).

Does endometrial cancer spread quickly?

The most common type of endometrial cancer (type 1) grows slowly. It most often is found only inside the uterus. Type 2 is less common. It grows more rapidly and tends to spread to other parts of the body.

Is metastatic endometrial cancer curable?

While endometrial cancer is a highly curable malignancy when it presents as a uterine-confined disease, the prognosis for recurrent or metastatic disease is poor. The median survival of women enrolled in trials for recurrent or metastatic endometrial cancer hardly exceeds 12 months [7].

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What happens once cancer has metastasized?

In metastasis, cancer cells break away from where they first formed (primary cancer), travel through the blood or lymph system, and form new tumors (metastatic tumors) in other parts of the body. The metastatic tumor is the same type of cancer as the primary tumor.

What is the last stage of uterus cancer?

Stage IVA: The cancer has spread to the bladder or rectum, and possibly nearby lymph nodes. Stage IVB: It’s found in the upper abdomen, the fat that supports your lower abdomen (called the omentum), or organs like your lungs, liver, and bones. It may have spread to the groin lymph nodes.

How long can you live with untreated endometrial cancer?

Five other cases of untreated endometrial carcinoma were found in the literature. The patients had varying length of survival (range: 5 months to 12 years), but all patients experienced generally good health several years after diagnosis.

What happens when endometrial cancer spreads to the brain?

Headache was the most common neurologic symptom (5/12, 41.7%), followed by focal weakness (3/12, 25.0%) and aphasia (3/12, 25.0%). In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common.

Do you have pain with endometrial cancer?

Pelvic pain, a mass, and weight loss

Pain in the pelvis, feeling a mass (tumor), and losing weight without trying can also be symptoms of endometrial cancer. These symptoms are more common in later stages of the disease.

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