What is the role of tumor treating fields in newly diagnosed glioblastoma?


What is the importance of tumor treating field?

A device, termed tumor-treating fields, delivers low intensity, intermediate-frequency alternating electric fields. Alternating electric fields disrupt mitosis leading to apoptosis of rapidly dividing cells in both cellular and animal models.

What is the standard treatment for glioblastoma?

Current standard therapy for glioblastoma is surgery to remove as much tumor tissue as possible, followed by treatment with radiation and the chemotherapy drug temozolomide (Temodar®).

Are there any new treatments for glioblastoma?

A new FDA-approved treatment involving electric fields alternating at 200 kHz called Optune™ therapy is now available for recurrent GBM as monotherapy and in combination with temozolomide for newly diagnosed GBM (3, 4). It is also being tested in clinical trials for other cancers.

What is the latest treatment for glioblastoma multiforme?

Chemotherapy with the drug temozolomide is the current standard of treatment for GBM. The drug is generally administered every day during radiation therapy and then for six cycles after radiation during the maintenance phase.

What is a contraindication for the use of tumor treating fields?

Contraindications. Contraindications may be either absolute (the treatment should not be used), or relative (the treatment may be used but caution should be observed). Other contraindications include people who deep brain stimulators, and in people who have skull defects (due the risk of skin damage).

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What is the longest someone has lived with glioblastoma?

Hillburn is now the study’s longest, and only, survivor. Half of the patients diagnosed with glioblastoma multiforme die of the disease within 14½ months, even with surgery, radiation and chemotherapy.

What happens in the final stages of glioblastoma?

Seizures occurred in nearly half of the patients in the end-of-life phase and more specifically in one-third of the patients in the week before dying. Other common symptoms reported in the end-of-life phase are progressive neurological deficits, incontinence, progressive cognitive deficits, and headache.

Is there any hope for glioblastoma?

Research and Medical Technology Advances Offer Hope for Patients with Aggressive Brain Cancer. Glioblastoma (GBM) is a highly lethal type of brain cancer that is notoriously difficult to treat. While the 5-year survival rate for all types of brain cancer is 33%, GBM has a 5-year survival rate of only 5%.

How long can you live with glioblastoma stage 4 without treatment?

Glioblastoma (GBM) remains the most common and most aggressive primary brain tumor, with a median survival of merely 3–4 months without treatment [Omuro and DeAngelis, 2013].

Does CBD help glioblastoma?

In over 20 animal studies, CBD/THC was found to drastically decrease the size of and even eliminate glioblastoma. Furthermore, in a few clinical trials and published reports, the variable anti-glioblastoma effects of these two cannabinoids, in combination with other therapeutic modalities, have been demonstrated.

Can glioblastoma be completely removed?

The type of brain tumor known as glioblastoma (GBM) is one of the most difficult cancers to treat. Complete removal by surgery is impossible because of where and how these tumors infiltrate brain tissue.

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