Is transitional cell carcinoma aggressive?
Transitional Cell Carcinoma: An Aggressive Cancer. Transitional cell carcinoma affects the transitional cells of the urinary system and accounts for an overwhelming majority of bladder cancer diagnoses. This cancer may spread rapidly, affecting other organs and becoming life-threatening in some cases.
How long do you live with transitional cell carcinoma?
Overall survival and cancer-specific survival
For the entire cohort, there were 986 (51.6%) patients who died and 704 (36.9%) patients who died from primary transitional cell carcinoma of the ureter. The median overall survival (OS) was 46 months, and the 5-year OS rate was 41.8%.
How serious is transitional cell carcinoma?
If it’s high grade, it’s more likely to spread to deeper layers of your bladder, other areas of your body, and your lymph nodes. It’s also likely to come back after treatment. High-grade TCC is the type of bladder cancer that is more likely to be life-threatening.
What is the primary symptom of transitional cell carcinoma?
The symptoms of transitional cell cancer of the kidney are similar to those of other types of kidney cancer. They include blood in the urine and pain in your back, between the lower ribs, and the top of your hip bone. You may also need to pass urine very often or have pain when passing urine.
Can you survive transitional cell carcinoma?
Transitional cell carcinoma of the renal pelvis, accounting for only 7% of all kidney tumors, and transitional cell cancer of the ureter, accounting for only 1 of every 25 upper urinary tract tumors, are curable in more than 90% of patients if they are superficial and confined to the renal pelvis or ureter.
What is the most aggressive type of bladder cancer?
Tumors can be low or high grade. High-grade tumor cells are very abnormal, poorly organized and tend to be more serious. They are the most aggressive and more likely to grow into the bladder muscle.
Where does transitional cell carcinoma metastasis?
Transitional cell carcinoma (TCC) of the bladder commonly metastasizes to the pelvic lymph nodes, lungs, liver, bones, adrenals, or brain. Unusual sites include the heart, kidney, spleen, pancreas, and reproductive system.
What happens if your ureter is removed?
If a large section is removed, tissue is used to repair the ureter. This tissue is taken from another part of the body, such as the bladder. The cut ends of the ureter are then stitched together.
What causes TCC?
The exact cause of upper urinary tract TCC is not known; however, several risk factors have been identified. Workers in the chemical, petrochemical, aniline dye, and plastics industries, as well as those exposed to coal, coke, tar, and asphalt, are at increased risk for renal pelvis and ureteral tumors.
What is high grade urothelial carcinoma?
Low-grade papillary urothelial carcinoma: These tumors tend to grow slowly, but they can come back after treatment. High-grade papillary urothelial carcinoma: These tumors grow more quickly and are more likely to spread.