What percent of ovarian cancer is platinum resistant?


How common is platinum resistant ovarian cancer?

Although up to 25% of women with ovarian cancer have innately (or primary) platinum-refractory disease, most patients are sensitive to front-line platinum therapy but will unfortunately develop recurrence and acquire progressive resistance over time.

How many people have platinum resistant ovarian cancer?

19 out of 29 were ovarian or peritoneal cancer. 17 out of 26 were platinum-resistant. 19 out of 30 were platinum-resistant.

What is the most aggressive form of ovarian cancer?

Grade 3 ovarian cancer: Grade 3 ovarian cancer tumours grow quickly and in a disorganised way. They are the most aggressive type of cancer.

What does platinum resistant ovarian cancer mean?

“Platinum resistant” ovarian cancer was historically defined as disease recurrence within 6months of completion of first-line platinum-based chemotherapy, although this is now more broadly applied to also include patients progressing within 6months after multiple lines of chemotherapy.

What is the difference between platinum sensitive and platinum-resistant?

Patients with a PFI of six months or longer are considered to have chemotherapy-sensitive disease (often also termed “platinum-sensitive”). Patients with a PFI of less than six months are considered to have chemotherapy-resistant disease (often also termed “platinum-resistant”).

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How is platinum-resistant ovarian cancer treated?

What are the treatment recommendations for platinum-resistant recurrent ovarian cancer?

  1. Liposomal doxorubicin 40-50 mg/m2 IV over 30 min; every 21 d [31,32,33] or.
  2. Gemcitabine 1000 mg/m² IV over 30 min on Days 1 and 8; every 21 d [32,33,34] or.

How can you prevent ovarian cancer relapse?

New research in mice identifies a compound that prevents ovarian cancer recurrence by eradicating the cancer stem-like cells that conventional chemotherapy leaves behind. Share on Pinterest New findings could change the face of ovarian cancer treatment.

What does platinum sensitive mean?

Some cancers that respond to treatment but then come back after a certain period may also be considered platinum sensitive. For example, ovarian cancer that comes back 6 or more months after platinum-based treatment is considered platinum sensitive.

What does platinum refractory mean?

For example, “platinum-refractory” is defined as cases in which the disease progresses during platinum-based therapy; “platinum-resistant” is defined as cases in which the disease relapses within 6 months after the end of platinum treatment; and “platinum-sensitive” is defined as cases in which the disease relapses at …

What are the signs that ovarian cancer has spread?

When ovarian cancer reaches an advanced stage and spreads to other areas of the body, symptoms are much more likely to occur.

How do I know if my ovarian cancer has spread?

  • Fatigue.
  • Constipation.
  • Vomiting and nausea.
  • Upset stomach.
  • Back pain.
  • Abdominal swelling with weight loss.

What is the mortality rate of ovarian cancer?

Ovarian cancer survival rates are much lower than other cancers that affect women. The relative five-year survival rate for ovarian cancer is 48% percent. Women diagnosed at an early stage—before the cancer has spread—have a much higher five-year survival rate than those diagnosed at a later stage.

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What is the least aggressive ovarian cancer?

That’s called a low malignant potential (LMP) tumor, or borderline epithelial ovarian cancer. It’s less life-threatening than other epithelial cancer, because it doesn’t grow as fast and spread the same way.