Contribution of EBV latent infection to oncogenesis
Which of the following malignancy is associated with EBV?
EBV infection increases a person’s risk of getting nasopharyngeal cancer (cancer of the area in the back of the nose) and certain types of fast-growing lymphomas such as Burkitt lymphoma. It may also be linked to Hodgkin lymphoma and some cases of stomach cancer.
What complication associated with EBV causes malignancy of epithelial cells?
EBV is linked to the pathogenesis of lymphomas such as Burkitt’s lymphoma (BL), Hodgkin lymphoma (HL) and post-transplant lympho-proliferative disorder (PTLD). Epithelial malignancies that are associated with EBV in epithelia cells include nasopharyngeal cancer (NPC), gastric cancer (GC) and breast cancer (BC) 34.
How does EBV infect epithelial cells?
EBV can infect both epithelial cells and B cells. Viral gp42 functions as the switch of tropism between epithelial cells and B cells. EBV produced from B cells have a higher tropism for infecting epithelial cells than B cells and vice versa.
Which cells are infected by Epstein Barr virus?
Human B cells are the primary targets of Epstein Barr virus (EBV) infection. In most cases EBV infection is asymptomatic because of a highly effective host immune response but some individuals develop self-limiting infectious mononucleosis, while others develop EBV-associated lymphoid or epithelial malignancies.
What condition is caused by Epstein-Barr virus?
Epstein-Barr virus, or EBV, is one of the most common human viruses in the world. It spreads primarily through saliva. EBV can cause infectious mononucleosis, also called mono, and other illnesses. Most people will get infected with EBV in their lifetime and will not have any symptoms.
What kills Epstein-Barr virus?
Ascorbic Acid Kills Epstein-Barr Virus (EBV) Positive Burkitt Lymphoma Cells and EBV Transformed B-Cells in Vitro, but not in Vivo. Amber N.
The Epstein-Barr virus, and the viruses that cause influenza, and hepatitis B and C have all been implicated in the development of fibromyalgia. “These viruses may have [long-term] effects on the immune system.
What are the long term effects of Epstein Barr?
Chronic active Epstein-Barr virus infection (CAEBV) is a very rare complication of an Epstein Barr virus (EBV) infection. Symptoms of CAEBV may include fever, swollen lymph nodes , and an enlarged liver and/or spleen.
Does EBV infect epithelial cells?
EBV readily infects B cells in vitro and transforms them into proliferative lymphoblastoid cell lines. In contrast, infection of human epithelial cells in vitro with EBV has been difficult to achieve.
What is the route of primary infection by Epstein Barr virus and which human cells does it infect?
EPIDEMIOLOGY AND RISK FACTORS
Epstein‐Barr virus (EBV) is a human B lymphotropic virus, the causative agent of infectious mononucleosis. The major route of transmission of EBV is through saliva, and EBV infects the epithelial cells of the oropharynx and adjacent structures as well as those of the uterine cervix.
How serious is Epstein-Barr virus?
If a teenager or adult is infected, they may experience symptoms like fatigue, swollen lymph nodes, and fever. In very rare cases, EBV can cause a chronic infection, which can be fatal if left untreated. EBV has also been linked with a variety of conditions, including cancers and autoimmune disorders.
Does Epstein-Barr ever go away?
EBV never truly goes away. Even if the symptoms subside, the virus will remain inactive inside your body until it is reactivated by a trigger. Some triggers include stress, a weakened immune system, taking immunosuppressants, or hormonal changes such as menopause.