Is Flot chemotherapy effective?


What is Flot chemotherapy?

What is FLOT? FLOT is used to treat oesophageal cancer (gullet) and stomach cancer cancer. It is best to read this information with our general information about chemotherapy and the type of cancer you have. FLOT is named after the initials of the drugs used in the treatment.

How many cycles of FLOT chemotherapy are there?

The FLOT regimen is a new standard of care for patients who can tolerate triplet chemotherapy. The standard of care for patients with operable gastric cancer has been pre- and postoperative chemotherapy with three cycles of epirubicin, cisplatin, and 5-FU (ECF).

How does Flot chemo work?

How does FLOT work? Fluorouracil, oxaliplatin and docetaxel are chemotherapy drugs. These chemotherapy drugs destroy quickly dividing cells, such as cancer cells. Leucovorin is a drug that helps fluorouracil to work better.

How often is Flot given?

Your treatment

FLOT (fluorouracil, leucovorin, oxaliplatin, docetaxel)
This treatment cycle is repeated every 14 days. You will have 8 cycles. The first 4 cycles are given before surgery and the next 4 cycles are given after surgery.
Day Treatment How long it takes
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Why can’t chemo patients have ice?

You are being treated for cancer with a chemotherapy medication called Oxaliplatin. This medication has an unusual side effect called “cold dysesthesia”. This means that different parts of your body may be very sensitive to cold – cold drinks, cold food, and cool or cold outdoor temperatures.

What does chemo do to your stomach?

Chemotherapy-induced abdominal pain, cramping and flatulence: Chemotherapy can cause both increased (rapid) and decreased (slow) motility of the intestines. In other words, the normal wave-like action that moves stool through the bowel may be faster or slower than usual.

What is the most common side effect of docetaxel?

The most common adverse reactions across all TAXOTERE indications are infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin …

Is leucovorin folic acid?

Leucovorin is in a class of medications called folic acid analogs. It works by protecting healthy cells from the effects of methotrexate or similar medications while allowing methotrexate to enter and kill cancer cells.

What is in Folfirinox?

An abbreviation for a chemotherapy combination used to treat pancreatic cancer that has spread to other parts of the body. It includes the drugs leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin. Also called FOLFIRINOX.

What neoadjuvant chemotherapy means?

(NEE-oh-A-joo-vant THAYR-uh-pee) Treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy.

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What is fluoropyrimidine based chemotherapy?

(FLOOR-oh-py-RIH-mih-deen) One of a group of substances used to treat cancer. A fluoropyrimidine is a type of antimetabolite. Examples are capecitabine, floxuridine, and fluorouracil (5-FU).

Who makes oxaliplatin?

The sanofi-aventis Group announced today that it has received marketing approval from the United States Food and Drug Administration for a new aqueous solution formulation of ELOXATIN™ (oxaliplatin injection).

What is neoadjuvant Flot?

Neoadjuvant chemotherapy with docetaxel, oxaliplatin, fluorouracil, and leucovorin (FLOT regimen) has shown promising results in terms of pathological response and survival rate in patients with locally advanced resectable gastric cancer (LAGC).

What is D2 gastrectomy?

D2 total gastrectomy includes the removal of lymph node stations 1 to 12a, while D2 distal gastrectomy includes D1 lymphadenectomy + the removal of the 8a, 9, 11p, and 12a lymph node groups.